Susceptibility to chronic inflammatory demyelinating polyradiculoneuropathy is associated to polymorphic GA repeat in the SH2D2A gene
Copyright policy )Susceptibility to chronic inflammatory demyelinating polyradiculoneuropathy is associated to polymorphic GA repeat in the SH2D2A gene
The SH2D2A gene encodes a T-cell-specific adapter protein involved in the negative control of T-cell activation. The genotype GA13-16 homozygote of the SH2D2A gene promoter has been associated with the susceptibility to develop multiple sclerosis. Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an immune-mediated neuropathy sharing several pathogenetic mechanisms with multiple sclerosis. We genotyped the SH2D2A promoter region in 105 controls and 48 patients with CIDP. We found a significant association between CIDP and the genotype GA13-16 homozygote (OR 3.167; p 0.013). We hypothesize that this genotype is associated with the susceptibility to develop CIDP and may be implicated in the persistence of the disease.
- Canadian Institutes of Health Research Canada
- Institute of Aging Canada
- Foundation University Islamabad Pakistan
- University of Chieti-Pescara Italy
Adult, Aged, 80 and over, Male, Chi-Square Distribution, Polymorphism, Genetic, Adolescent, Genotype, Middle Aged, Gene Frequency, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating, Confidence Intervals, Odds Ratio, Humans, Female, Genetic Predisposition to Disease, Child, Dinucleotide Repeats, Promoter Regions, Genetic, Adaptor Proteins, Signal Transducing, Aged
Adult, Aged, 80 and over, Male, Chi-Square Distribution, Polymorphism, Genetic, Adolescent, Genotype, Middle Aged, Gene Frequency, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating, Confidence Intervals, Odds Ratio, Humans, Female, Genetic Predisposition to Disease, Child, Dinucleotide Repeats, Promoter Regions, Genetic, Adaptor Proteins, Signal Transducing, Aged
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).30 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!