Identification of MIM23, a putative component of the protein import machinery of the mitochondrial inner membrane
Copyright policy )Identification of MIM23, a putative component of the protein import machinery of the mitochondrial inner membrane
A screening for yeast mutants impaired in mitochondrial protein import led to the identification of two genes (MPI1 and MPI2) encoding the essential components MIM44 and MIM17 of the inner membrane import machinery. We analyzed twelve additional mutants obtained in the screening and found two further complementation groups. One group represents mutants of SSC1, the gene encoding mitochondrial hsp70, an essential matrix protein required for protein import across the inner membrane. The second complementation group represents mutants of a new gene (MPI3) encoding a 23 kDa integral inner membrane protein (MIM23). MIM23 is synthesized without a presequence, and its import to the inner membrane requires a membrane potential. MIM23 contains a domain homologous to half of MIM17. We speculate that MIM23 is a new member of the protein import machinery of the mitochondrial inner membrane.
- Institute of Molecular and Cell Biology Singapore
- University of Freiburg Germany
- Agency for Science, Technology and Research Singapore
Protein translocation, Saccharomyces cerevisiae Proteins, Base Sequence, Sequence Homology, Amino Acid, MIM23, Molecular Sequence Data, Membrane Proteins, Membrane Transport Proteins, Biological Transport, Intracellular Membranes, Saccharomyces cerevisiae, Mitochondrial inner membrane, Mitochondria, Fungal Proteins, Mitochondrial Precursor Protein Import Complex Proteins, Mutation, Amino Acid Sequence, Carrier Proteins, DNA, Fungal
Protein translocation, Saccharomyces cerevisiae Proteins, Base Sequence, Sequence Homology, Amino Acid, MIM23, Molecular Sequence Data, Membrane Proteins, Membrane Transport Proteins, Biological Transport, Intracellular Membranes, Saccharomyces cerevisiae, Mitochondrial inner membrane, Mitochondria, Fungal Proteins, Mitochondrial Precursor Protein Import Complex Proteins, Mutation, Amino Acid Sequence, Carrier Proteins, DNA, Fungal
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