Translational Regulation of Human Papillomavirus Type 16 E7 mRNA by the Peptide SEQIKA, Shared by Rabbit α1-Globin and Human Cytokeratin 7
Copyright policy )Translational Regulation of Human Papillomavirus Type 16 E7 mRNA by the Peptide SEQIKA, Shared by Rabbit α1-Globin and Human Cytokeratin 7
ABSTRACTThe possible biochemical factors able to affect the in vitro expression of the high-risk human papillomavirus type 16 (HPV16) E7 oncoprotein have been analyzed. Evidence is provided that E7 mRNA stability is increased and, conversely, transcript translation is inhibited by binding to a 32-kDa protein from rabbit reticulocyte lysate; sequence analysis identified the 32-kDa binding protein as rabbit α1-globin protein; and interaction between rabbit α1-globin and E7 mRNA occurs through the 6-mer peptide SEQIKA present in human cytokeratin 7 protein. The in vitro data were confirmed by the occurrence of HPV16 E7 mRNA-cytokeratin 7 binding in squamous cervical cancer SiHa cells.
Papillomavirus E7 Proteins, Keratin-7, Molecular Sequence Data, Oncogene Proteins, Viral, Globins, Mice, Inbred C57BL, Mice, Protein Biosynthesis, Tumor Cells, Cultured, Animals, Humans, Keratins, Female, Amino Acid Sequence, RNA, Messenger, Rabbits, Peptides
Papillomavirus E7 Proteins, Keratin-7, Molecular Sequence Data, Oncogene Proteins, Viral, Globins, Mice, Inbred C57BL, Mice, Protein Biosynthesis, Tumor Cells, Cultured, Animals, Humans, Keratins, Female, Amino Acid Sequence, RNA, Messenger, Rabbits, Peptides
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