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Effect of Number of Haptens per Carrier Molecule on an Adoptive Secondary Anti-Hapten Response

Authors: S, Kontiainen;

Effect of Number of Haptens per Carrier Molecule on an Adoptive Secondary Anti-Hapten Response

Abstract

Primary antihapten response to a monovalent conjugate of NIP (4-hydroxy-3-iodo-5-nitrophenylacetic acid) and bovine serum albumin (BSA) tended to be rich in 7S and primary response to a polyvalent conjugate NIP<sub>34</sub>-BSA rich in 19S anti-NIP antibodies. Monovalent conjugate NIP<sub>1.1</sub>-BSA tended to boost cells primed with polyvalent conjugates of NIP to a secondary anti-NIP response rich in 7S and polyvalent conjugate, NIP<sub>34</sub>-BSA, to a response rich in 19S anti-NIP antibodies. Monovalent conjugate, NIP<sub>1.1</sub>-BSA, did not prime the cells detectably, although it induced a primary antihapten response.

Related Organizations
Keywords

Immunization, Passive, Rats, Inbred Strains, Serum Albumin, Bovine, Nitro Compounds, Antibodies, Rats, Radiation Effects, Immunoglobulin M, Immunoglobulin G, Animals, Female, Immunization, Carrier Proteins, Haptens, Immunologic Memory, Phenylacetates

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    14
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
Powered by OpenAIRE graph
Found an issue? Give us feedback
selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
14
Average
Top 10%
Average
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