Distribution and functional diversification of the ras superfamily inSaccharomyces cerevisiae
Copyright policy )Distribution and functional diversification of the ras superfamily inSaccharomyces cerevisiae
The recent availability of the fullSaccharomyces cerevisiaegenome sequence offers a first opportunity to analyze the composition, function and evolution of GTPases in the ras‐p21 superfamily. This superfamily in yeast is composed of 29 proteins divided into five families: ras with four sequences implicated in cell signalling; rho, six genes related to the cell shape machinery; ypt‐rab, ten proteins with different roles in intracellular trafficking; arf‐sar, seven proteins related to vesicular trafficking in secretory pathways; and ran, two proteins acting as components of the nuclear transport system. The superfamily covers a wide range of cellular functions from signalling to intracellular trafficking, while conserving the structural framework and a common mechanism of GTP hydrolysis.
Genome, p21, Saccharomyces cerevisiae, Oncogene Protein p21(ras), Yeast, GTP Phosphohydrolases, Evolution, Molecular, Schizosaccharomyces, Humans, Genome, Fungal, Ras
Genome, p21, Saccharomyces cerevisiae, Oncogene Protein p21(ras), Yeast, GTP Phosphohydrolases, Evolution, Molecular, Schizosaccharomyces, Humans, Genome, Fungal, Ras
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