Abstract In order to determine the stabilization (resonance) energies of nitrogenous heterocyclic compounds, the generalized valence bond orbital interactions (GVB-OIs) have been considered within the cyclic periphery of 2 p z -GVB orbitals. The overall process of GVB-OIs goes through a number of successive three-electron interactions (known as Pauli's orbital interactions (POIs)), each of which involves interaction between the two 2 p z -GVB bonding orbitals and the one 2 p z -GVB nonbonding orbital, and occurs following Pauli's principle. After taking into account the total number of POIs involved and their associated minimization energies, the stabilization energies (SE)/resonance energies (RE) of mononitrogenous five- and six-membered heterocyclic compounds have been calculated by the formulae derived for them. The SE/RE values of polynitrogenous heterocyclic compounds have been calculated individually.