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CARM1 Methylates Chromatin Remodeling Factor BAF155 to Enhance Tumor Progression and Metastasis

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2014 English Publisher:Elsevier BVJournal:Cancer Cell, volume 30, pages 179-180 (issn: 1535-6108,

Authors: J. Wesley Pike; Sandeep Saha; Menggang Yu; Weibo Cai; Paul Ahlquist; Paul Ahlquist; Wei Xu; +8 Authors

doi: 10.1016/j.ccell.2016.06.013 , 10.1016/j.ccr.2013.12.007

pmid: 27479032 , 24434208

pmc: PMC4004525

CARM1 Methylates Chromatin Remodeling Factor BAF155 to Enhance Tumor Progression and Metastasis

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Abstract

Coactivator-associated arginine methyltransferase 1 (CARM1), a coactivator for various cancer-relevant transcription factors, is overexpressed in breast cancer. To elucidate the functions of CARM1 in tumorigenesis, we knocked out CARM1 from several breast cancer cell lines using Zinc-Finger Nuclease technology, which resulted in drastic phenotypic and biochemical changes. The CARM1 KO cell lines enabled identification of CARM1 substrates, notably the SWI/SNF core subunit BAF155. Methylation of BAF155 at R1064 was found to be an independent prognostic biomarker for cancer recurrence and to regulate breast cancer cell migration and metastasis. Furthermore, CARM1-mediated BAF155 methylation affects gene expression by directing methylated BAF155 to unique chromatin regions (e.g., c-Myc pathway genes). Collectively, our studies uncover a mechanism by which BAF155 acquires tumorigenic functions via arginine methylation.

Related Organizations

Howard Hughes Medical Institute
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Morgridge Institute for Research
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Cell Signaling Technology (United States)
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University of Wisconsin–Oshkosh
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University of Wisconsin–Madison
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Keywords

Mice, Knockout, Cancer Research, Protein-Arginine N-Methyltransferases, Blotting, Western, Breast Neoplasms, Cell Biology, DNA Methylation, Chromatin Assembly and Disassembly, Gene Expression Regulation, Neoplastic, Mice, Oncology, Tissue Array Analysis, Cell Line, Tumor, Disease Progression, Animals, Humans, Female, Neoplasm Invasiveness, Oligonucleotide Array Sequence Analysis, Transcription Factors

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