Genomic dissection of the cell-type-specification circuit in Saccharomyces cerevisiae
Copyright policy )Genomic dissection of the cell-type-specification circuit in Saccharomyces cerevisiae
The budding yeast Saccharomyces cerevisiae has three cell types (a cells, α cells, and a/α cells), each of which is specified by a unique combination of transcriptional regulators. This transcriptional circuit has served as an important model for understanding basic features of the combinatorial control of transcription and the specification of cell type. Here, using genome-wide chromatin immunoprecipitation, transcriptional profiling, and phylogenetic comparisons, we describe the complete cell-type-specification circuit for S . cerevisiae . We believe this work represents a complete description of cell-type specification in a eukaryote.
- University of California, Davis United States
- University of California System United States
- University of California, San Francisco United States
- University of Oregon United States
Chromatin Immunoprecipitation, Osmosis, Binding Sites, Models, Genetic, Transcription, Genetic, Genes, Fungal, Saccharomyces cerevisiae, Sodium Chloride, Evolution, Molecular, Open Reading Frames, Gene Expression Regulation, Fungal, Genome, Fungal, Phylogeny, Oligonucleotide Array Sequence Analysis, Protein Binding
Chromatin Immunoprecipitation, Osmosis, Binding Sites, Models, Genetic, Transcription, Genetic, Genes, Fungal, Saccharomyces cerevisiae, Sodium Chloride, Evolution, Molecular, Open Reading Frames, Gene Expression Regulation, Fungal, Genome, Fungal, Phylogeny, Oligonucleotide Array Sequence Analysis, Protein Binding
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