The HTL1 gene (YCR020W‐b) of Saccharomyces cerevisiae is necessary for growth at 37°C, and for the conservation of chromosome stability and fertility
Copyright policy )The HTL1 gene (YCR020W‐b) of Saccharomyces cerevisiae is necessary for growth at 37°C, and for the conservation of chromosome stability and fertility
AbstractA small 78 codon ORF, named HTL1 (Chen et al., unpublished results), situated between loci MAK31 and HSP30 on chromosome III of Saccharomyces cerevisiae, is required for growth at 37°C. In this communication, we characterize the ORF and show that disruption of HTL1, besides preventing growth at 37°C, causes genetic and/or epigenetic instability at 26°C: ploidy increases in about 10% of cells grown from individual disruptants and a fraction of disruptant clones are predestined to a rapid and progressive loss of fertility during growth at 26°C. Copyright © 2001 John Wiley & Sons, Ltd.
- University Federico II of Naples Italy
- National Research Council Sri Lanka
- International Institute of Minnesota United States
- Institute of Genetics and Biophysics Italy
- National Research Council Italy
electroporation, Saccharomyces cerevisiae Proteins, Transcription, Genetic, Genes, Fungal, Molecular Sequence Data, chromosome segregation, Saccharomyces cerevisiae HTL1, Saccharomyces cerevisiae, yeast, thermolability, Open Reading Frames, Chromosome Segregation, Amino Acid Sequence, Cloning, Molecular, Frameshift Mutation, Ploidies, Base Sequence, Genetic Complementation Test, Temperature, ploidy, Sequence Analysis, DNA, Physical Chromosome Mapping, Chromosomes, Fungal, genome stability, Gene Deletion
electroporation, Saccharomyces cerevisiae Proteins, Transcription, Genetic, Genes, Fungal, Molecular Sequence Data, chromosome segregation, Saccharomyces cerevisiae HTL1, Saccharomyces cerevisiae, yeast, thermolability, Open Reading Frames, Chromosome Segregation, Amino Acid Sequence, Cloning, Molecular, Frameshift Mutation, Ploidies, Base Sequence, Genetic Complementation Test, Temperature, ploidy, Sequence Analysis, DNA, Physical Chromosome Mapping, Chromosomes, Fungal, genome stability, Gene Deletion
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