Parkinson's Disease Iron Deposition Caused by Nitric Oxide-Induced Loss of β-Amyloid Precursor Protein
Copyright policy )Parkinson's Disease Iron Deposition Caused by Nitric Oxide-Induced Loss of β-Amyloid Precursor Protein
Elevation of both neuronal iron and nitric oxide (NO) in the substantia nigra are associated with Parkinson's disease (PD) pathogenesis. We reported previously that the Alzheimer-associated β-amyloid precursor protein (APP) facilitates neuronal iron export. Here we report markedly decreased APP expression in dopaminergic neurons of human PD nigra and thatAPP−/−mice develop iron-dependent nigral cell loss. Conversely, APP-overexpressing mice are protected in the MPTP PD model. NO suppresses APP translation in mouse MPTP models, explaining how elevated NO causes iron-dependent neurodegeneration in PD.
- University of Melbourne Australia
- University of Technology Sydney Australia
- Harvard University United States
- Florey Institute of Neuroscience and Mental Health Australia
- University of Leeds United Kingdom
Male, 570, Dopaminergic Neurons, Iron, 610, MPTP Poisoning, Parkinson Disease, Nitric Oxide, Mice, Inbred C57BL, Substantia Nigra, Amyloid beta-Protein Precursor, Mice, Cell Line, Tumor, Animals, Humans, Female
Male, 570, Dopaminergic Neurons, Iron, 610, MPTP Poisoning, Parkinson Disease, Nitric Oxide, Mice, Inbred C57BL, Substantia Nigra, Amyloid beta-Protein Precursor, Mice, Cell Line, Tumor, Animals, Humans, Female
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