Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity
Copyright policy )Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity
SARS-CoV-2 from alpha to epsilon As battles to contain the COVID-19 pandemic continue, attention is focused on emerging variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus that have been deemed variants of concern because they are resistant to antibodies elicited by infection or vaccination or they increase transmissibility or disease severity. Three papers used functional and structural studies to explore how mutations in the viral spike protein affect its ability to infect host cells and to evade host immunity. Gobeil et al . looked at a variant spike protein involved in transmission between minks and humans, as well as the B1.1.7 (alpha), B.1.351 (beta), and P1 (gamma) spike variants; Cai et al . focused on the alpha and beta variants; and McCallum et al . discuss the properties of the spike protein from the B1.1.427/B.1.429 (epsilon) variant. Together, these papers show a balance among mutations that enhance stability, those that increase binding to the human receptor ACE2, and those that confer resistance to neutralizing antibodies. —VV
- Los Alamos National Laboratory United States
- Durham University United Kingdom
- Duke University United States
Models, Molecular, Protein Conformation, Cryoelectron Microscopy, COVID-19, Antibodies, Viral, Host Adaptation, Antibodies, Neutralizing, Protein Subunits, Amino Acid Substitution, Mink, Mutation, Animals, Humans, Protein Interaction Domains and Motifs, Angiotensin-Converting Enzyme 2, Protein Structure, Quaternary, Antigens, Viral, Research Articles, Immune Evasion, Protein Binding, Receptors, Coronavirus
Models, Molecular, Protein Conformation, Cryoelectron Microscopy, COVID-19, Antibodies, Viral, Host Adaptation, Antibodies, Neutralizing, Protein Subunits, Amino Acid Substitution, Mink, Mutation, Animals, Humans, Protein Interaction Domains and Motifs, Angiotensin-Converting Enzyme 2, Protein Structure, Quaternary, Antigens, Viral, Research Articles, Immune Evasion, Protein Binding, Receptors, Coronavirus
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