JAK/STAT signaling by cytokine receptors
Copyright policy )JAK/STAT signaling by cytokine receptors
The JAK/STAT pathway is recognized as one of the major mechanisms by which cytokine receptors transduce intracellular signals. This system is regulated at multiple levels, including JAK activation, nuclear trafficking of STAT factors, and negative feedback loops. Gene deletion studies have implicated selected STAT factors as predominant mediators for a limited number of lymphokines. This signaling pathway influences normal cell survival and growth mechanisms and may contribute to oncogenic transformation.
- University of California System United States
- Gladstone Institutes United States
- University of California, San Francisco United States
Mice, Knockout, Apoptosis, Protein-Tyrosine Kinases, Feedback, DNA-Binding Proteins, src Homology Domains, Mice, Cell Transformation, Neoplastic, Gene Expression Regulation, Gene Targeting, Trans-Activators, Animals, Genes, Lethal, Interferons, Phosphorylation, Receptors, Cytokine, Dimerization, Protein Processing, Post-Translational, Signal Transduction
Mice, Knockout, Apoptosis, Protein-Tyrosine Kinases, Feedback, DNA-Binding Proteins, src Homology Domains, Mice, Cell Transformation, Neoplastic, Gene Expression Regulation, Gene Targeting, Trans-Activators, Animals, Genes, Lethal, Interferons, Phosphorylation, Receptors, Cytokine, Dimerization, Protein Processing, Post-Translational, Signal Transduction
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