descriptionPublicationkeyboard_double_arrow_right Article 29 Jun 2016 English Publisher:American Chemical Society (ACS)Journal:Organic Letters, volume 18, pages 3,506-3,508 (issn: 1523-7060, eissn: 1523-7052,

Authors: Kaga, Atsushi; Tnay, Ya Lin; Chiba, Shunsuke;

doi: 10.1021/acs.orglett.6b01669

pmid: 27355342

Synthesis of Fasicularin

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Abstract

The synthesis of a tricyclic marine alkaloid, fasicularin, was accomplished. Stereoselective synthesis of the aza-spirocyclic BC-ring precursor and ensuing construction of the A-ring with stereocontrolled installation of the C2 hexyl group feature prominently in the synthesis.

Related Organizations

Nanyang Technological University
Singapore

Keywords

Transfer Reactions, :Chemistry [Science], Aziridines

15 Research products, page 1 of 2

Total Synthesis of the Tricyclic Marine Alkaloids (‐)‐Lepadiformine, (+)‐Cylindricine C, and (‐)‐Fasicularin via a Common Intermediate Formed by Formic Acid‐Induced Intramolecular Conjugate Azaspirocyclization.
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