Low back pain (lumbodynia) is a most common reason for seeking medical care and a most common of disability. The review presents current clinical guidelines for the management of patients with acute nonspecific lumbodynia. The diagnosis of acute nonspecific lumbodynia is based on clinical findings and, in most cases, requires no instrumental studies. Nonsteroidal anti-inflammatory drugs are most effective in reducing pain. Additional therapies, such as therapeutic exercises, manual therapy, massage, acupuncture, etc., are discussed. There are data on the use of B vitamins, Milgamma® in particular, in acute non-specific lumbalgia.