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Fatal Puumala Hantavirus Disease: Involvement of Complement Activation and Vascular Leakage in the Pathobiology

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Jan 2017 Finland, Sweden English Publisher:Oxford University Press (OUP)Journal:Open Forum Infectious Diseases, volume 4 (eissn: 2328-8957, Copyright policy )
Authors: Sironen, Tarja; Sane, Jussi; Lokki, Marja-Liisa; Meri, Seppo; Andersson, Leif C.; Hautala, Timo; Kauma, Heikki; +5 Authors

doi: 10.1093/ofid/ofx229

pmid: 29255728

pmc: PMC5726462

handle: 10138/231541

Fatal Puumala Hantavirus Disease: Involvement of Complement Activation and Vascular Leakage in the Pathobiology

Abstract

AbstractThe case-fatality rate of hantavirus disease depends strongly on the causative hantavirus, ranging from 0.1% to 40%. However, the pathogenesis is not fully understood, and at present no licensed therapies exist. We describe fatal cases caused by Puumala hantavirus indicating involvement of complement activation and vascular leakage.

Countries
Finland, Sweden
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Keywords

Infectious Medicine, complement activation, case fatality rate, Brief Report, PATHOGENESIS, Infektionsmedicin, puumala virus, case-fatality rate, Puumala virus, vascular leakage, hantavirus, NEPHROPATHIA-EPIDEMICA, Biomedicine, HEMORRHAGIC-FEVER, INFECTION, VIRUS, complement

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 15
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Average
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
15
Top 10%
Average
Average
Green
gold
Related to Research communities
Knowmad Institut
UArctic