Powered by OpenAIRE graph
Found an issue? Give us feedback
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Nature Medicinearrow_drop_down
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
Nature Medicine
Article
Data sources: UnpayWall
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
https://www.nature.com/article...
Article
Data sources: UnpayWall
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
PubMed Central
Other literature type . 2021
License: http://creativecommons.org/licenses/by-nd/4.0/This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, and only so long as attribution is given to the creator. The license allows for commercial use.
Data sources: PubMed Central
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Nature Medicine
Article . 2021 . Peer-reviewed
License: Springer TDM
Data sources: Crossref
https://doi.org/10.1101/2021.0...
Article . 2021 . Peer-reviewed
Data sources: Crossref
https://pubmed.ncbi.nlm.nih.go...
Article . 2021
Data sources: Europe PubMed Central
https://pubmed.ncbi.nlm.nih.go...
Article
Data sources: Europe PubMed Central
Nature Medicine
Article
Data sources: Microsoft Academic Graph
https://biorxiv.org/content/10...
Other literature type
Data sources: Microsoft Academic Graph
UP Research Data Repository
Article . 2021
Data sources: Bielefeld Academic Search Engine (BASE)
 View all 5 versions
Claim

This Research product is the result of merged Research products in OpenAIRE.

You have already added 0 works in your ORCID record related to the merged Research product.

SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 19 Jan 2021 English Publisher:Springer Science and Business Media LLCJournal:Nature Medicine, volume 27, pages 622-625 (issn: 1078-8956, eissn: 1546-170X, Copyright policy )Funded by:NIH | IP16-003, Research on the..., WT | Characterization of SARS-..., NIH | Research training in HIV-... +2 projects
Authors: Tandile Hermanus; Michael T. Boswell; Cheryl Cohen; Cheryl Cohen; Bronwen E. Lambson; Bronwen E. Lambson; Frances Ayres; +19 Authors

doi: 10.1038/s41591-021-01285-x , 10.1101/2021.01.18.427166

pmid: 33654292 , 33501446

pmc: PMC7836116

handle: 2263/79329

SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma

Abstract

AbstractSARS-CoV-2 501Y.V2 (B.1.351), a novel lineage of coronavirus causing COVID-19, contains substitutions in two immunodominant domains of the spike protein. Here, we show that pseudovirus expressing 501Y.V2 spike protein completely escapes three classes of therapeutically relevant antibodies. This pseudovirus also exhibits substantial to complete escape from neutralization, but not binding, by convalescent plasma. These data highlight the prospect of reinfection with antigenically distinct variants and foreshadows reduced efficacy of spike-based vaccines.

Related Organizations
View all View all
Keywords

COVID-19 Vaccines, SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), COVID-19 pandemic, COVID-19, Blood Donors, Antibodies, Viral, Article, Coronavirus disease 2019 (COVID-19), Neutralization Tests, Spike Glycoprotein, Coronavirus, Infectious diseases, Humans, Immune Evasion

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 1K
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 0.01%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 0.1%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 0.01%
Powered by OpenAIRE graph
Found an issue? Give us feedback
selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
1K
Top 0.01%
Top 0.1%
Top 0.01%
Green
bronze
Related to Research communities
Corona Virus Disease
Knowmad Institut