The conformation of the main immunogenic region on the α‐subunit of muscle acetylcholine receptor is affected by neighboring receptor subunits
Copyright policy )The conformation of the main immunogenic region on the α‐subunit of muscle acetylcholine receptor is affected by neighboring receptor subunits
Myasthenia gravis (MG) is caused by autoantibodies to the acetylcholine receptor (AChR). Experiments with fetal (α2βγδ) and adult (α2βϵδ) AChR and with recombinant subunit dimers showed that some monoclonal antibodies (mAbs) against the main immunogenic region (MIR), located on the α‐subunit of the AChR, bind better to fetal AChR and to αγ subunit dimer than to adult AChR and αϵ dimer and equally to both αβ and αδ. However, other anti‐MIR mAbs prefer adult AChR and αϵ dimer, bind well to αβ but weakly to αδ. These results suggest that the MIR conformation is affected by the neighboring γ/ϵ‐ and δ‐subunits and may contribute to understanding the antibody specificities in MG.
- John Radcliffe Hospital United Kingdom
- University of Oxford United Kingdom
- Pasteur Hellenic Institute Greece
- Institut Pasteur France
- Institute of Molecular Medicine India
Monoclonal antibody, Aging, Protein Conformation, Radioimmunoassay, Antibodies, Monoclonal, Cell Line, Epitopes, Mice, Epitope conformation, Fetus, Antibody Specificity, Myasthenia Gravis, Animals, Receptors, Cholinergic, Acetylcholine receptor, Main immunogenic region, Dimerization
Monoclonal antibody, Aging, Protein Conformation, Radioimmunoassay, Antibodies, Monoclonal, Cell Line, Epitopes, Mice, Epitope conformation, Fetus, Antibody Specificity, Myasthenia Gravis, Animals, Receptors, Cholinergic, Acetylcholine receptor, Main immunogenic region, Dimerization
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