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The molecular mechanism of axonal transport of tetanus toxin in vivo and in vitro

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 23 Sep 2008 English Publisher:Springer Science and Business Media LLCJournal:BMC Proceedings, volume 2 (eissn: 1753-6561,

Authors: Sara Salinas; Giampietro Schiavo; Lynsey G. Bilsland;

doi: 10.1186/1753-6561-2-s1-s4

The molecular mechanism of axonal transport of tetanus toxin in vivo and in vitro

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Abstract

In this study we established an in vivo assay allowing the visualization and quantitative analysis of axonal transport in the sciatic nerve of living mice during disease progression. To fulfill this task, we exploit a fragment of tetanus toxin (HC). HC enters motor neurons at the NMJ and is targeted to the soma located in the spinal cord. HC entry relies on a specialized clathrin-mediated pathway, which requires a specific subset of small GTPases. The transport route of HC is shared with several neurotrophins and their receptors.

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London Research Institute
United Kingdom

76 Research products, page 1 of 8

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