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Rheb Is Essential for Murine Development

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2011 English Publisher:Informa UK LimitedJournal:Molecular and Cellular Biology, volume 31, pages 1,672-1,678 (eissn: 1098-5549, Copyright policy )
Authors: Henricus J. Duckers; Caroline Cheng; Mark Nellist; Susanna M.I. Goorden; Marianne Hoogeveen-Westerveld; Laura Post; Geeske M. van Woerden; +2 Authors

doi: 10.1128/mcb.00985-10

pmid: 21321084

pmc: PMC3126339

Rheb Is Essential for Murine Development

Abstract

Ras homolog enriched in brain (Rheb) couples growth factor signaling to activation of the target of rapamycin complex 1 (TORC1). To study its role in mammals, we generated a Rheb knockout mouse. In contrast to mTOR or regulatory-associated protein of mTOR (Raptor) mutants, the inner cell mass of Rheb(-/-) embryos differentiated normally. Nevertheless, Rheb(-/-) embryos died around midgestation, most likely due to impaired development of the cardiovascular system. Rheb(-/-) embryonic fibroblasts showed decreased TORC1 activity, were smaller, and showed impaired proliferation. Rheb heterozygosity extended the life span of tuberous sclerosis complex 1-deficient (Tsc1(-/-)) embryos, indicating that there is a genetic interaction between the Tsc1 and Rheb genes in mouse.

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Keywords

Mice, Knockout, Heterozygote, Tumor Suppressor Proteins, Neuropeptides, Gene Expression Regulation, Developmental, Embryo, Mammalian, Tuberous Sclerosis Complex 1 Protein, Rats, EMC ONWAR-01-94-01, Mice, Animals, Ras Homolog Enriched in Brain Protein, EMC MGC-02-96-01, Cells, Cultured, EMC COEUR-09, Monomeric GTP-Binding Proteins

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    		 68
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    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
68
Top 10%
Top 10%
Top 10%
bronze
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