Epigenetic Spreading of the Drosophila Dosage Compensation Complex from roX RNA Genes into Flanking Chromatin
Copyright policy )Epigenetic Spreading of the Drosophila Dosage Compensation Complex from roX RNA Genes into Flanking Chromatin
The multisubunit MSL dosage compensation complex binds to hundreds of sites along the Drosophila single male X chromosome, mediating its hypertranscription. The male X chromosome is also coated with noncoding roX RNAs. When either msl3, mle, or mof is mutant, a partial MSL complex is bound at only approximately 35 unusual sites distributed along the X. We show that two of these sites are the roX1 and roX2 genes and postulate that one of their functions is to provide entry sites for the MSL complex to recognize the X chromosome. The roX1 gene provides a nucleation site for extensive spreading of the MSL complex into flanking chromatin even when moved to an autosome. The spreading can occur in cis or in trans between paired homologs. We present a model for how the dosage compensation complex recognizes X chromatin.
Male, Models, Genetic, Biochemistry, Genetics and Molecular Biology(all), Nuclear Proteins, RNA-Binding Proteins, Genes, Insect, DNA, Chromatin, DNA-Binding Proteins, Evolution, Molecular, Drosophila melanogaster, Gene Expression Regulation, Species Specificity, Dosage Compensation, Genetic, Animals, Drosophila Proteins, Insect Proteins, RNA, Drosophila, Protein Binding, Transcription Factors
Male, Models, Genetic, Biochemistry, Genetics and Molecular Biology(all), Nuclear Proteins, RNA-Binding Proteins, Genes, Insect, DNA, Chromatin, DNA-Binding Proteins, Evolution, Molecular, Drosophila melanogaster, Gene Expression Regulation, Species Specificity, Dosage Compensation, Genetic, Animals, Drosophila Proteins, Insect Proteins, RNA, Drosophila, Protein Binding, Transcription Factors
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