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Evidence for a Myotomal Hox/Myf Cascade Governing Nonautonomous Control of Rib Specification within Global Vertebral Domains

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2010 Portugal English Publisher:Elsevier BVJournal:Developmental Cell, volume 18, pages 655-661 (issn: 1534-5807,

Copyright policy )Funded by:FCT | The molecular mechanisms ..., FCT | MECHANISMS OF HOX FUNCTIO..., FCT | MOLECULAR CONTROL OF HEMA...

Authors: Joana Bom; Tânia Vinagre; Moisés Mallo; Moisés Mallo; Natalia Moncaut; Ana Nóvoa; Marta Carapuço;

doi: 10.1016/j.devcel.2010.02.011

pmid: 20412779

handle: 10400.7/669

Evidence for a Myotomal Hox/Myf Cascade Governing Nonautonomous Control of Rib Specification within Global Vertebral Domains

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Abstract

Hox genes are essential for the patterning of the axial skeleton. Hox group 10 has been shown to specify the lumbar domain by setting a rib-inhibiting program in the presomitic mesoderm (PSM). We have now produced mice with ribs in every vertebra by ectopically expressing Hox group 6 in the PSM, indicating that Hox genes are also able to specify the thoracic domain. We show that the information provided by Hox genes to specify rib-containing and rib-less areas is first interpreted in the myotome through the regional-specific control of Myf5 and Myf6 expression. This information is then transmitted to the sclerotome by a system that includes FGF and PDGF signaling to produce vertebrae with or without ribs at different axial levels. Our findings offer a new perspective of how Hox genes produce global patterns in the axial skeleton and support a redundant nonmyogenic role of Myf5 and Myf6 in rib formation.

Country

Portugal

Related Organizations

University of Lisbon
Portugal
Instituto Gulbenkian de Ciencia
Portugal
university of lisbon
Portugal
Calouste Gulbenkian Foundation
Portugal
Universidade de Lisboa
Portugal

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Keywords

Homeodomain Proteins, Platelet-Derived Growth Factor, Bone Development, Models, Genetic, Gene Expression Regulation, Developmental, DEVBIO, Mice, Transgenic, Muscle Development, Models, Biological, Fibroblast Growth Factors, Mice, Homeobox A10 Proteins, Phenotype, Myogenic Regulatory Factors, Animals, Myogenic Regulatory Factor 5, Developmental Biology

39 Research products, page 1 of 4

Platelet-derived growth factor subunit A
2017IsRelatedTo
Pax1 protein
2017IsRelatedTo
Homeobox protein Hox-A10
2017IsRelatedTo
Fibroblast growth factor 4
2017IsRelatedTo
Paired box protein Pax-3
2017IsRelatedTo
Paired box protein Pax-1
2017IsRelatedTo
Uncharacterized protein
2017IsRelatedTo
Platelet-derived growth factor subunit A
2017IsRelatedTo
Homeobox protein Hox-A11
2017IsRelatedTo
PAX3/FKHR fusion
2017IsRelatedTo

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