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Genomics
Article . 1992 . Peer-reviewed
License: Elsevier TDM
Data sources: Crossref
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Genomics
Article . 1992
Data sources: Europe PubMed Central
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Genomics
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Human-mouse homologies in the region of the polycystic kidney disease gene (PKD1)

descriptionPublicationkeyboard_double_arrow_right Article 01 May 1992 English Publisher:Elsevier BVJournal:Genomics, volume 13, pages 35-38 (issn: 0888-7543, Copyright policy )
Authors: Gregory G. Germino; Stephen T. Reeders; Angela Snarey; Debra Weinstat-Saslow; Anna Maria Frischauf; Heinz Himmelbauer; Stefan Somlo; +1 Authors

doi: 10.1016/0888-7543(92)90198-2

pmid: 1349580

Human-mouse homologies in the region of the polycystic kidney disease gene (PKD1)

Abstract

Autosomal dominant polycystic kidney disease (PKD1) is linked to the alpha-globin locus near the telomere of chromosome 16p. We established the existence of a conserved linkage group in mouse by mapping conserved sequences and cDNAs from the region surrounding the PKD1 gene in the mouse genome. Results obtained with the BXD recombinant strain system and somatic cell hybrids show the homologous region to be located on mouse chromosome 17 near the globin pseudogene Hba-ps4, an unprocessed alpha-like globin gene. The markers we mapped are widely distributed over the region known to contain the PKD1 gene, and it is therefore likely that the mouse homologue of PKD1 is also located on mouse chromosome 17.

Related Organizations
Keywords

Genetic Markers, Polycystic Kidney Diseases, Genetic Linkage, Globins, Mice, Inbred C57BL, Blotting, Southern, Mice, Mice, Inbred DBA, Sequence Homology, Nucleic Acid, Animals, Humans, Chromosomes, Human, Pair 16, Polymorphism, Restriction Fragment Length, Pseudogenes

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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 29
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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    influence
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    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
29
Average
Top 10%
Top 10%
gold