AbstractThere is an unavoidable development in the progress of science; nanotechnology has been part of the mainstream scientific theory with potential medical and dental applications since the early 1990s. Dentistry is undergoing another change with the help of nanotechnology combined with nanomaterials, biotechnology and ultimately dental nanorobotics. Nanodentistry will make possible maintenance of comprehensive oral health by employing nano tissue devices which will allow precise controlled oral analgesia, dentine replacement therapy, permanent hypersensitivity cure and complete orthodontic realignment etc., all in a single office visit, covalently bonded diamondized enamel and continuous oral health maintenance through the use of mechanical dentifrobots. There is an increase in optimism that nanotechnology applied to dentistry will bring significant advances in the diagnosis, treatment and prevention of disease. This article enlightens about potential applications of nanotechnology in dentistry and to illustrate their potentially far reaching impact on clinical dental practice.