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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Blood Purificationarrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Blood Purification
Article . 2011 . Peer-reviewed
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Individualised Dialysate Temperature Improves Intradialytic Haemodynamics and Abrogates Haemodialysis-Induced Myocardial Stunning, without Compromising Tolerability

Authors: Jefferies, HJ; Burton, JO; McIntyre, CW;

Individualised Dialysate Temperature Improves Intradialytic Haemodynamics and Abrogates Haemodialysis-Induced Myocardial Stunning, without Compromising Tolerability

Abstract

<i>Background/Aims:</i> Haemodialysis-induced myocardial stunning is associated with intradialytic hypotension, increased likelihood of cardiovascular events and death. Dialysis at 35°C reduces stunning, but adverse thermal symptoms limit technique adoption. This study investigated whether individualised body temperature dialysis improves haemodynamic stability and abrogates stunning. <i>Methods:</i> Randomised crossover study of 11 patients compared LV regional wall motion abnormalities (RWMAs) at 37°C (HD<sub>37</sub>) and body temperature (‘individualised’, HD<sub>ind</sub>). Regional systolic function was quantitatively assessed by echocardiography. Haemodynamics were assessed using continuous pulse wave analysis. Thermal symptoms were scored by questionnaire. <i>Results:</i> Mean predialysis body temperature was 36.0 ± 0.1°C. Mean number of peak stress RWMAs per patient was lower with HD<sub>ind</sub> (3.9 ± 1.4 vs. 5.3 ± 1.5, p = 0.03). Intradialytic systolic BP was higher during HD<sub>ind</sub> versus HD<sub>37</sub> (p < 0.001). Individualised body temperature dialysis demonstrated symptomatic tolerability comparable to HD<sub>37</sub>. <i>Conclusions:</i> Individualised-temperature haemodialysis abrogates stunning, providing effective haemodynamic stabilisation at no additional therapy cost.

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Keywords

Male, Systole, Heart Ventricles, Blood Pressure, Body Temperature, Kidney Failure, Renal Dialysis, Dialysis Solutions, 80 and over, Humans, Prospective Studies, Chronic, Precision Medicine, Aged, Aged, 80 and over, Myocardial Stunning, Cross-Over Studies, Hemodynamics, Temperature, Individualized Medicine, Middle Aged, Echocardiography, Kidney Failure, Chronic, Female

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
66
Top 10%
Top 10%
Top 10%
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