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Drosophila NURF-55, a WD repeat protein involved in histone metabolism

descriptionPublicationkeyboard_double_arrow_right Article 06 Jan 1998 Spain English Publisher:Proceedings of the National Academy of SciencesJournal:Proceedings of the National Academy of Sciences, volume 95, pages 132-137 (issn: 0027-8424, eissn: 1091-6490,

Authors: Martínez-Balbás, Marian; Tsukiyama, Toshio; Gdula, David; Wu, Carl;

doi: 10.1073/pnas.95.1.132

pmid: 9419341

pmc: PMC18150

handle: 10261/124660

Drosophila NURF-55, a WD repeat protein involved in histone metabolism

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Abstract

The Drosophila nucleosome remodeling factor (NURF) is a protein complex of four distinct subunits that assists transcription factor-mediated chromatin remodeling. One NURF subunit, ISWI, is related to the transcriptional regulators Drosophila brahma and yeast SWI2/SNF2. We have determined peptide sequences and isolated cDNA clones for a second NURF component (the 55-kDa subunit). Immunological studies show that p55 is an integral subunit of NURF and is generally associated with polytene chromosomes. The predicted sequence of p55 reveals a WD repeat protein that is identical with the 55-kDa subunit of the Drosophila chromatin assembly factor (CAF-1). Given that WD repeat proteins related to p55 are associated with histone deacetylase and histone acetyltransferase, our findings suggest that p55 and its homologs may function as a common platform for the assembly of protein complexes involved in chromatin metabolism.

Country

Spain

Related Organizations

Spanish National Research Council
Spain
National Institute of Health
Pakistan
National Institutes of Health
United States
Medical Research Council
United Kingdom
National Cancer Institute
United States

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Keywords

Saccharomyces cerevisiae Proteins, Chromosomal Proteins, Non-Histone, Molecular Sequence Data, Nuclear Proteins, Chromatin, DNA-Binding Proteins, Histones, Chromatin Assembly Factor-1, Acetyltransferases, Animals, Drosophila Proteins, Insect Proteins, Drosophila, Amino Acid Sequence, Retinoblastoma-Binding Protein 4, Fluorescent Antibody Technique, Indirect, Histone Acetyltransferases, Molecular Chaperones

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