Blimp1 Defines a Progenitor Population that Governs Cellular Input to the Sebaceous Gland
Copyright policy )Blimp1 Defines a Progenitor Population that Governs Cellular Input to the Sebaceous Gland
Epidermal lineage commitment occurs when multipotent stem cells are specified to three lineages: the epidermis, the hair follicle, and the sebaceous gland (SG). How and when a lineage becomes specified remains unknown. Here, we report the existence of a population of unipotent progenitor cells that reside in the SG and express the transcriptional repressor Blimp1. Using cell-culture studies and genetic lineage tracing, we demonstrate that Blimp1-expressing cells are upstream from other cells of the SG lineage. Blimp1 appears to govern cellular input into the gland since its loss leads to elevated c-myc expression, augmented cell proliferation, and SG hyperplasia. Finally, BrdU labeling experiments demonstrate that the SG defects associated with loss of Blimp1 lead to enhanced bulge stem cell activity, suggesting that when normal SG homeostasis is perturbed, multipotent stem cells in the bulge can be mobilized to correct this imbalance.
- New York University United States
- RIKEN Center for Biosystems Dynamics Research Japan
- Howard Hughes Medical Institute United States
- University of Leeds United Kingdom
- Rockefeller University United States
Mice, Knockout, Hyperplasia, Biochemistry, Genetics and Molecular Biology(all), Multipotent Stem Cells, Gene Expression Regulation, Developmental, Cell Count, Cell Differentiation, Epithelial Cells, Mice, Transgenic, Proto-Oncogene Proteins c-myc, Repressor Proteins, Mice, Animals, Newborn, Bromodeoxyuridine, Cell Movement, Animals, Cell Lineage, Positive Regulatory Domain I-Binding Factor 1, Hair Follicle, Cells, Cultured, Cell Proliferation
Mice, Knockout, Hyperplasia, Biochemistry, Genetics and Molecular Biology(all), Multipotent Stem Cells, Gene Expression Regulation, Developmental, Cell Count, Cell Differentiation, Epithelial Cells, Mice, Transgenic, Proto-Oncogene Proteins c-myc, Repressor Proteins, Mice, Animals, Newborn, Bromodeoxyuridine, Cell Movement, Animals, Cell Lineage, Positive Regulatory Domain I-Binding Factor 1, Hair Follicle, Cells, Cultured, Cell Proliferation
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