A mouse model for Down syndrome exhibits learning and behaviour deficits
Copyright policy )A mouse model for Down syndrome exhibits learning and behaviour deficits
Trisomy 21 or Down syndrome (DS) is the most frequent genetic cause of mental retardation, affecting one in 800 live born human beings. Mice with segmental trisomy 16 (Ts65Dn mice) are at dosage imbalance for genes corresponding to those on human chromosome 21q21-22.3--which includes the so-called DS 'critical region'. They do not show early-onset of Alzheimer disease pathology; however, Ts65Dn mice do demonstrate impaired performance in a complex learning task requiring the integration of visual and spatial information. The reproducibility of this phenotype among Ts65Dn mice indicates that dosage imbalance for a gene or genes in this region contributes to this impairment. The corresponding dosage imbalance for the human homologues of these genes may contribute to cognitive deficits in DS.
- Johns Hopkins Medicine United States
- Johns Hopkins University United States
- Jackson Laboratory United States
- Johns Hopkins University School of Medicine United States
- University of Oxford United Kingdom
Male, Analysis of Variance, Mice, Inbred C3H, Sex Characteristics, Amyloid beta-Peptides, Chromosomes, Human, Pair 21, Chromosome Mapping, Gene Expression, Motor Activity, Mice, Inbred C57BL, Disease Models, Animal, Mice, Mice, Neurologic Mutants, Alzheimer Disease, Animals, Humans, Learning, Female, Down Syndrome
Male, Analysis of Variance, Mice, Inbred C3H, Sex Characteristics, Amyloid beta-Peptides, Chromosomes, Human, Pair 21, Chromosome Mapping, Gene Expression, Motor Activity, Mice, Inbred C57BL, Disease Models, Animal, Mice, Mice, Neurologic Mutants, Alzheimer Disease, Animals, Humans, Learning, Female, Down Syndrome
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