P-OTX: a PIT-1-interacting homeodomain factor expressed during anterior pituitary gland development.
Copyright policy )P-OTX: a PIT-1-interacting homeodomain factor expressed during anterior pituitary gland development.
A novel OTX-related homeodomain transcription factor has been identified on the basis of its ability to interact with the transactivation domain of the pituitary-specific POU domain protein, Pit-1. This factor, referred to as P-OTX (pituitary OTX-related factor), is expressed in primordial Rathke's pouch, oral epithelium, first bronchial arch, duodenum, and hindlimb. In the developing anterior pituitary, it is expressed in all regions from which cells with distinct phenotypes will emerge in the mature gland. P-OTX is able to independently activate and to synergize with Pit-1 on pituitary-specific target gene promoters. Therefore, P-OTX may subserve functions in generating both precursor and specific cell phenotypes in the anterior pituitary gland and in several other organs.
- University of California, San Diego United States
- Howard Hughes Medical Institute United States
- University of California, San Diego United States
Homeodomain Proteins, Transcriptional Activation, Duodenum, Molecular Sequence Data, Gene Expression, Gene Expression Regulation, Developmental, Epithelium, Hindlimb, DNA-Binding Proteins, Embryonic and Fetal Development, Mice, Branchial Region, Phenotype, Organ Specificity, Pituitary Gland, Anterior, Animals, Paired Box Transcription Factors, Transcription Factor Pit-1, Gene Library, Transcription Factors
Homeodomain Proteins, Transcriptional Activation, Duodenum, Molecular Sequence Data, Gene Expression, Gene Expression Regulation, Developmental, Epithelium, Hindlimb, DNA-Binding Proteins, Embryonic and Fetal Development, Mice, Branchial Region, Phenotype, Organ Specificity, Pituitary Gland, Anterior, Animals, Paired Box Transcription Factors, Transcription Factor Pit-1, Gene Library, Transcription Factors
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