The 7p15.3 (rs4487645) association for multiple myeloma shows strong allele-specific regulation of the MYC-interacting gene CDCA7L in malignant plasma cells
Copyright policy )The 7p15.3 (rs4487645) association for multiple myeloma shows strong allele-specific regulation of the MYC-interacting gene CDCA7L in malignant plasma cells
Recent genome-wide association studies have identified single nucleotide polymorphisms (SNPs) at 7 loci influencing multiple myeloma (MM) risk. We generated expression quantitative trait loci (eQTL) data on malignant plasma cells on 848 patients to fine map the risk loci associations and gain
- LMU Klinikum Germany
- National Center for Tumor Diseases Germany
- Leeds Teaching Hospitals NHS Trust United Kingdom
- Hôpital Saint Eloi France
- St James's University Hospital United Kingdom
Male, Plasma Cells, Quantitative Trait Loci, Multiple Myeloma/genetics, Signal transduction, eQTL, Polymorphism, Single Nucleotide, Proto-Oncogene Proteins c-myc, single nucleotide polymorphism, Humans, Diseases of the blood and blood-forming organs, Alleles, risk, Aged, Repressor Proteins/genetics, Binding Sites, Interferon Regulatory Factors/genetics, Plasma Cells/metabolism, Chromosome Mapping, Hematology, Middle Aged, multiple myeloma, Gene Expression Regulation, Neoplastic, Repressor Proteins, Interferon Regulatory Factors, Female, Proto-Oncogene Proteins c-myc/genetics, RC633-647.5, Multiple Myeloma, Chromosomes, Human, Pair 7, Protein Binding, Signal Transduction
Male, Plasma Cells, Quantitative Trait Loci, Multiple Myeloma/genetics, Signal transduction, eQTL, Polymorphism, Single Nucleotide, Proto-Oncogene Proteins c-myc, single nucleotide polymorphism, Humans, Diseases of the blood and blood-forming organs, Alleles, risk, Aged, Repressor Proteins/genetics, Binding Sites, Interferon Regulatory Factors/genetics, Plasma Cells/metabolism, Chromosome Mapping, Hematology, Middle Aged, multiple myeloma, Gene Expression Regulation, Neoplastic, Repressor Proteins, Interferon Regulatory Factors, Female, Proto-Oncogene Proteins c-myc/genetics, RC633-647.5, Multiple Myeloma, Chromosomes, Human, Pair 7, Protein Binding, Signal Transduction
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