Mouse Atf5: Molecular Cloning of Two Novel mRNAs, Genomic Organization, and Odorant Sensory Neuron Localization
Copyright policy )Mouse Atf5: Molecular Cloning of Two Novel mRNAs, Genomic Organization, and Odorant Sensory Neuron Localization
The activating transcription factor (ATF) family comprises a group of basic region-leucine zipper (bZIP) proteins, which have roles in the development of species as diverse as insects and mammals. Here we describe two novel mRNAs encoding a single, 30-kDa mouse polypeptide, designated mouse ATF5, which is 58% identical to mouse ATF4 in the carboxy-terminal bZIP region. Both transcripts harbor highly complex 5' untranslated regions that impede translation of the ATF5 open reading frame. The mouse and human ATF5 loci consist of at least four exons contained within 5 kb of genomic sequence. During mouse embryonic development, expression of Atf5 is pronounced at the late gestational period and appears to be confined to cells of the neuronal layers of the olfactory epithelium and vomeronasal organ. This suggests a role for ATF5 in odorant sensory neuron differentiation.
- University of Copenhagen Denmark
- University of Copenhagen Denmark
- University of Copenhagen Denmark
Base Sequence, Molecular Sequence Data, Synteny, Activating Transcription Factors, Smell, Alternative Splicing, Mice, Animals, Humans, Amino Acid Sequence, Neurons, Afferent, Vomeronasal Organ, Transcription Factors
Base Sequence, Molecular Sequence Data, Synteny, Activating Transcription Factors, Smell, Alternative Splicing, Mice, Animals, Humans, Amino Acid Sequence, Neurons, Afferent, Vomeronasal Organ, Transcription Factors
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).55 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!