The mouse adducin gene family: alternative splicing and chromosomal localization
Copyright policy )The mouse adducin gene family: alternative splicing and chromosomal localization
Mouse cDNA sequences encoding alpha, beta, and gamma adducins were cloned from a mouse reticulocyte cDNA library. The purified clones contain alternatively spliced exons from all three adducin genes. In the case of alpha and beta, the inclusion of the alternatively spliced exons results in truncated polypeptide isoforms (called alpha-2 and beta-2). The mouse predicted amino acid sequences are compared with published rat and human sequences. For completion of this comparison, cDNA encoding the rat beta-1 carboxy terminus was cloned by PCR. The carboxy terminal region containing MARCKS homology, calmodulin-binding region-2, and spectrin-actin-binding site, is conserved among alpha-1, beta-1, and gamma-1 isoforms in mouse, rat, and humans. We also report here the localization of the gene encoding gamma adducin (Add3) to murine Chr 19, in a region that shows conserved synteny with human Chr 10.
- Yale University United States
- Jackson Laboratory United States
570, DNA, Complementary, Molecular Sequence Data, 610, Base-Sequence, Sequence-Alignment, Calmodulin-Binding-Proteins, Cytoskeletal-Proteins, Mice, SUPPORT-U-S-GOVT-P-H-S, Animals, Humans, Gene-Library, Amino Acid Sequence, Cloning, Molecular, SUPPORT-NON-U-S-GOVT, DNA Primers, Gene Library, DNA-Primers, Molecular-Sequence-Data, Sequence-Homology-Nucleic-Acid, Base Sequence, Sequence Homology, Amino Acid, Animal, Reverse Transcriptase Polymerase Chain Reaction, Tumor-Cells-Cultured, Chromosome Mapping, Sequence-Homology-Amino-Acid, Exons, Sequence Analysis, DNA, Cloning-Molecular, Rats, Reverse-Transcriptase-Polymerase-Chain-Reaction, Alternative Splicing, Cytoskeletal Proteins, Chromosome-Mapping, Sequence-Analysis-DNA, Amino-Acid-Sequence, Calmodulin-Binding Proteins, DNA-Complementary, Sequence Alignment, Human
570, DNA, Complementary, Molecular Sequence Data, 610, Base-Sequence, Sequence-Alignment, Calmodulin-Binding-Proteins, Cytoskeletal-Proteins, Mice, SUPPORT-U-S-GOVT-P-H-S, Animals, Humans, Gene-Library, Amino Acid Sequence, Cloning, Molecular, SUPPORT-NON-U-S-GOVT, DNA Primers, Gene Library, DNA-Primers, Molecular-Sequence-Data, Sequence-Homology-Nucleic-Acid, Base Sequence, Sequence Homology, Amino Acid, Animal, Reverse Transcriptase Polymerase Chain Reaction, Tumor-Cells-Cultured, Chromosome Mapping, Sequence-Homology-Amino-Acid, Exons, Sequence Analysis, DNA, Cloning-Molecular, Rats, Reverse-Transcriptase-Polymerase-Chain-Reaction, Alternative Splicing, Cytoskeletal Proteins, Chromosome-Mapping, Sequence-Analysis-DNA, Amino-Acid-Sequence, Calmodulin-Binding Proteins, DNA-Complementary, Sequence Alignment, Human
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).19 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!