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Haematologica
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Characterization of 35 new cases with four different MPLW515 mutations and essential thrombocytosis or primary myelofibrosis

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2009 English Publisher:Ferrata Storti Foundation (Haematologica)Journal:Haematologica, volume 94, pages 141-144 (issn: 0390-6078, eissn: 1592-8721, Copyright policy )
Authors: Petro E. Petrides; R Weide; R. Pihusch; Hans-Peter Laubenstein; Robert Dengler; Wolfgang Kern; Torsten Haferlach; +13 Authors

doi: 10.3324/haematol.13224

pmid: 19029146

pmc: PMC2625421

Characterization of 35 new cases with four different MPLW515 mutations and essential thrombocytosis or primary myelofibrosis

Abstract

Recently, mutations of MPL , the gene coding for the thrombopoetin receptor, were demonstrated in ~5% of cases of primary myelofibrosis (PMF) and in ~1% of all cases of essential thrombocytosis (ET).[1][1],[2][2] They represent gain-of-function mutations that confer constitutive activation of the

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Keywords

Adult, Aged, 80 and over, Male, Tryptophan, Middle Aged, Primary Myelofibrosis, Mutation, Humans, Diseases of the blood and blood-forming organs, Female, RC633-647.5, Receptors, Thrombopoietin, Aged, Thrombocythemia, Essential

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    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 62
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
62
Top 10%
Top 10%
Top 10%
gold
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