Maternal phosphatidylinositol 3‐kinase signalling is crucial for embryonic genome activation and preimplantation embryogenesis
Copyright policy )Maternal phosphatidylinositol 3‐kinase signalling is crucial for embryonic genome activation and preimplantation embryogenesis
Maternal effect factors derived from oocytes are important for sustaining early embryonic development before the major wave of embryonic genome activation (EGA). In this study, we report a two‐cell‐stage arrest of embryos lacking maternal 3‐phosphoinositide‐dependent protein kinase 1 as a result of suppressed EGA. Concurrent deletion of maternal Pten completely rescued the suppressed EGA and embryonic progression through restored AKT signalling, which fully restored the fertility of double‐mutant females. Our study identifies maternal phosphatidylinositol 3‐kinase signalling as a new maternal effect factor that regulates EGA and preimplantation embryogenesis in mice.
- Japanese Foundation For Cancer Research Japan
- Kobe University Japan
- Umeå University Sweden
Mice, Knockout, Genome, Cell Cycle, PTEN Phosphohydrolase, Embryonic Development, Gene Expression Regulation, Developmental, Pyruvate Dehydrogenase Acetyl-Transferring Kinase, Protein Serine-Threonine Kinases, Mice, Phosphatidylinositol 3-Kinases, Blastocyst, Pregnancy, Mutation, Animals, Female, Proto-Oncogene Proteins c-akt, Gene Deletion, Signal Transduction
Mice, Knockout, Genome, Cell Cycle, PTEN Phosphohydrolase, Embryonic Development, Gene Expression Regulation, Developmental, Pyruvate Dehydrogenase Acetyl-Transferring Kinase, Protein Serine-Threonine Kinases, Mice, Phosphatidylinositol 3-Kinases, Blastocyst, Pregnancy, Mutation, Animals, Female, Proto-Oncogene Proteins c-akt, Gene Deletion, Signal Transduction
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