Abstract Engineered solutions are becoming more complex and multi‐disciplinary in nature. This evolution requires new techniques to enhance design and analysis tasks that incorporate data integration and interoperability across various engineering tool suites spanning multiple domains at different abstraction levels. Semantic web technologies (SWT) offer data integration and interoperability benefits as well as other opportunities to enhance reasoning across knowledge represented in multiple disparate models. This paper introduces the digital engineering framework for integration and interoperability (DEFII) for incorporating SWT into engineering design and analysis tasks. The framework includes three notional interfaces for interacting with ontology‐aligned data. It also introduces a novel model interface specification diagram (MISD) that provides a tool‐agnostic model representation enabled by SWT that exposes data stored for use by external users through standards‐based interfaces. Use of the framework results in a tool‐agnostic authoritative source of truth spanning the entire project, system, or mission.