Vimentin coordinates fibroblast proliferation and keratinocyte differentiation in wound healing via TGF-β–Slug signaling
Copyright policy )Vimentin coordinates fibroblast proliferation and keratinocyte differentiation in wound healing via TGF-β–Slug signaling
Significance The central concept in this study is that a major cytoskeletal component, vimentin, acts as a signal integrator during wound healing, operating in both signal-triggering and signal-receiving cells. This is a previously unreported concept for intermediate filaments, with an evolving paradigm according to which intermediate filaments emerge as integrators of regeneration with specific functions in the particular tissues for which individual intermediate filaments are characteristic. Our study reveals the underlying molecular and cellular control functions of vimentin in vimentin-dependent epithelial–mesenchymal transition, regeneration, and healing.
- Umeå University Sweden
- University of British Columbia Canada
- St. Paul's Hospital Canada
- Åbo Akademi University Finland
- Turku Centre for Biotechnology Finland
Keratinocytes, Male, Mice, Knockout, Wound Healing, Epithelial-Mesenchymal Transition, Mice, 129 Strain, Gene Expression Profiling, Cell Differentiation, Fibroblasts, Mice, Inbred C57BL, Animals, Newborn, Transforming Growth Factor beta, Animals, Vimentin, ta318, Female, RNA Interference, Snail Family Transcription Factors, Cells, Cultured, Cell Proliferation, Signal Transduction
Keratinocytes, Male, Mice, Knockout, Wound Healing, Epithelial-Mesenchymal Transition, Mice, 129 Strain, Gene Expression Profiling, Cell Differentiation, Fibroblasts, Mice, Inbred C57BL, Animals, Newborn, Transforming Growth Factor beta, Animals, Vimentin, ta318, Female, RNA Interference, Snail Family Transcription Factors, Cells, Cultured, Cell Proliferation, Signal Transduction
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