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NF-Y is a CCAAT-specific transcription factor thought to be involved in the regulation of a variety of eukaryotic genes. It shows a striking sequence similarity with the yeast factor HAP2/3. In an attempt to trace back its evolutionary history, we succeeded in isolating NF-Y cDNA clones from a plant and from several species of vertebrates. The patterns of sequence conservation delineate potential functional domains: A central, highly conserved, domain likely responsible for DNA-binding and subunit interaction; more evolutionarily flexible flanking regions, in which variability is clustered, individualizing conserved glutamine or acidic amino-acids putatively involved in protein-protein contacts.
Base Sequence, Molecular Sequence Data, Fungi, Genetic Variation, Biological Evolution, Polymerase Chain Reaction, Zea mays, DNA-Binding Proteins, Structure-Activity Relationship, CCAAT-Enhancer-Binding Proteins, Animals, Humans, Amino Acid Sequence, Transcription Factors
Base Sequence, Molecular Sequence Data, Fungi, Genetic Variation, Biological Evolution, Polymerase Chain Reaction, Zea mays, DNA-Binding Proteins, Structure-Activity Relationship, CCAAT-Enhancer-Binding Proteins, Animals, Humans, Amino Acid Sequence, Transcription Factors
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | 152 | |
popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network. | Top 10% | |
influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | Top 10% | |
impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network. | Top 10% |