Assessment of miRNA reporters in EBV− cells. Reporter activity for miR-BART2-3p, miR-BART3-5p and controls was compared between AKBM and the EBV− Burkitt’s lymphoma cell lines, 2A8 and AK31 (AKBM data also shown in Fig. 1). The miR-BART2-3p reporter is only downregulated in AKBM but not in the other two cell lines, suggesting that downregulation of the reporter is specific for EBV+ cells and thus likely due to miR-BART2-3p expression. The miR-BART3-5p reporter was downregulated in all three cell lines, suggesting the influence of a common host cell factor such as a human miRNA on reporter expression (PDF 101 kb)