Structural Organization and Chromosomal Localization ofHyal2,a Gene Encoding a Lysosomal Hyaluronidase
Copyright policy )Structural Organization and Chromosomal Localization ofHyal2,a Gene Encoding a Lysosomal Hyaluronidase
The human HYAL2 gene encodes a lysosomal hyaluronidase that is related to the testicular PH-20 hyaluronidase. Regions conserved in these proteins have been used to design PCR primers suitable for the isolation of a fragment of the murine Hyal2 gene. This fragment was used to isolate the Hyal2 cDNA from a cDNA library. The cloned cDNA has an open reading frame of 473 codons and a 3'-untranslated region of 302 bases plus a poly(A) tail. Using this cDNA, the corresponding genomic DNA was characterized from 129SVJ mice. The murine Hyal2 gene is approximately 3.5 kb, contains the coding sequence for the mRNA on four exons, and is localized on chromosome 9 between the microsatellite markers D9Mit183 and D9Mit17 near the genes for dystroglycan and transferrin. The gene is expressed ubiquitously, the sole exception being adult brain.
- Austrian Academy of Sciences Austria
- Brigham and Women's Faulkner Hospital United States
Mice, Inbred BALB C, DNA, Complementary, Base Sequence, Sequence Homology, Amino Acid, Molecular Sequence Data, Brain, Chromosome Mapping, Hyaluronoglucosaminidase, Mice, Inbred Strains, Exons, Sequence Analysis, DNA, Introns, Mice, Untranslated Regions, Animals, Humans, Amino Acid Sequence, Lysosomes
Mice, Inbred BALB C, DNA, Complementary, Base Sequence, Sequence Homology, Amino Acid, Molecular Sequence Data, Brain, Chromosome Mapping, Hyaluronoglucosaminidase, Mice, Inbred Strains, Exons, Sequence Analysis, DNA, Introns, Mice, Untranslated Regions, Animals, Humans, Amino Acid Sequence, Lysosomes
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