Complete coding sequences and haplotypic associations of HLA‐B*0707, ‐B*1524, ‐B*4405, ‐B*4802, ‐DRB1*0409, ‐DRB1*0411, ‐DRB1*1115, ‐DRB1*1305, and the novel allele ‐DRB1*0709. Group‐specific amplification of cDNA from DRB1 alleles associated to DRB3 and DRB4
Copyright policy )Complete coding sequences and haplotypic associations of HLA‐B*0707, ‐B*1524, ‐B*4405, ‐B*4802, ‐DRB1*0409, ‐DRB1*0411, ‐DRB1*1115, ‐DRB1*1305, and the novel allele ‐DRB1*0709. Group‐specific amplification of cDNA from DRB1 alleles associated to DRB3 and DRB4
Abstract: We present here the characterization of the complete coding sequences, previously unavailable, of the human leukocyte antigen (HLA) alleles B*0707, B*1524, B*4405, B*4802, DRB1*0409, DRB1*0411, DRB1*1115, DRB1*1305, and that of a new allele, DRB1*0709. For the isolation of cDNA from the DRB1 gene, we designed a novel set of polymerase chain reaction (PCR) primers that makes it possible to amplify separately the groups of DRB1 alleles associated to each of the DRB3 and DRB4 loci. The primary structures, functional features, evolutionary relationships, haplotypic associations, and population distributions of each of the nine HLA‐B and ‐DRB1 alleles reported here are reviewed.
DNA, Complementary, Base Sequence, Sequence Homology, Amino Acid, Reverse Transcriptase Polymerase Chain Reaction, Molecular Sequence Data, HLA-DR Antigens, Sequence Analysis, DNA, Polymerase Chain Reaction, Evolution, Molecular, Haplotypes, HLA-B Antigens, Humans, Amino Acid Sequence, HLA-DRB3 Chains, 3' Untranslated Regions, Alleles, HLA-DRB4 Chains, Polymorphism, Single-Stranded Conformational, DNA Primers, HLA-DRB1 Chains
DNA, Complementary, Base Sequence, Sequence Homology, Amino Acid, Reverse Transcriptase Polymerase Chain Reaction, Molecular Sequence Data, HLA-DR Antigens, Sequence Analysis, DNA, Polymerase Chain Reaction, Evolution, Molecular, Haplotypes, HLA-B Antigens, Humans, Amino Acid Sequence, HLA-DRB3 Chains, 3' Untranslated Regions, Alleles, HLA-DRB4 Chains, Polymorphism, Single-Stranded Conformational, DNA Primers, HLA-DRB1 Chains
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).8 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!