David Tuckchow Yue, a renowned biophysicist who dedicated his life to the study of voltage-gated calcium (CaV) channels, passed away suddenly on December 23, 2014 from cardiac arrest. David was a passionate, dedicated, and brilliant scientist who pursued fundamental mechanistic understanding of CaV channel regulation with quantitative rigor, child-like wonder, and remarkable creativity. To those who knew him (both scientists and non-scientists alike), David's tremendous enthusiasm for science and the passion he brought to seeking truth was both infectious and inspirational.