Btk29A Promotes Wnt4 Signaling in the Niche to Terminate Germ Cell Proliferation in Drosophila
Copyright policy )Btk29A Promotes Wnt4 Signaling in the Niche to Terminate Germ Cell Proliferation in Drosophila
Wnt–β-Catenin in Germ Cells The Wnt–β-catenin pathway contributes to many signaling mechanisms during organismal development and carcinogenesis by regulating both transcription and cell adhesion. Hamada-Kawaguchi et al. (p. 294 ) demonstrate that this pathway must be activated in ovarian somatic cells to stop proliferation of germ cells in Drosophila. Phosphorylation of a tyrosine residue on β-catenin by the tyrosine kinase Btk turns on signaling in the niche cells by promoting transcriptional activity of β-catenin. Failure in this process resulted in ovarian tumors in the flies.
- Tohoku University Japan
- Karolinska Institute Sweden
- University of Sulaymaniyah Iraq
- Karolinska University Hospital Sweden
Transcription, Genetic, Protein-Tyrosine Kinases, Genomic Instability, Up-Regulation, Wnt Proteins, Drosophila melanogaster, Germ Cells, Gene Knockdown Techniques, Argonaute Proteins, Animals, Drosophila Proteins, Tyrosine, DNA Breaks, Double-Stranded, Phosphorylation, RNA, Small Interfering, beta Catenin, Cell Proliferation, Glycoproteins, Signal Transduction
Transcription, Genetic, Protein-Tyrosine Kinases, Genomic Instability, Up-Regulation, Wnt Proteins, Drosophila melanogaster, Germ Cells, Gene Knockdown Techniques, Argonaute Proteins, Animals, Drosophila Proteins, Tyrosine, DNA Breaks, Double-Stranded, Phosphorylation, RNA, Small Interfering, beta Catenin, Cell Proliferation, Glycoproteins, Signal Transduction
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