Lack of association between the Met196Arg polymorphism in the TNFR2 gene and autoimmune diseases accompanied by vasculitis including SLE in Japanese
Copyright policy )Lack of association between the Met196Arg polymorphism in the TNFR2 gene and autoimmune diseases accompanied by vasculitis including SLE in Japanese
Abstract:A polymorphism in high‐affinity receptor of TNF (TNFR2) gene, Met196Arg, was reported to be associated with systemic lupus erythematosus (SLE) in Japanese, whereas the association could not be found in Europeans at all and this represents an apparent discrepancy. The association, then, should be tested in other populations to clarify the possible involvement, if any, of the TNFR2 polymorphism in SLE or other related autoimmune diseases. The purposes of this study were to examine the TNFR2 polymorphism in Japanese patients with SLE and to investigate its association with other autoimmune diseases accompanied by vasculitis, mixed connective tissue disease, Buerger’s disease, and Takayasu’s arteritis. We found no association at all between the TNFR2 polymorphism and any autoimmune diseases including SLE in Japanese.
- Institute of Science Tokyo Japan
- Nagoya University Japan
- Tokai National Higher Education and Research System Japan
- Keio University Japan
- Juntendo University Japan
Vasculitis, Polymorphism, Genetic, Arginine, Receptors, Tumor Necrosis Factor, Autoimmune Diseases, Methionine, Amino Acid Substitution, Asian People, Japan, Antigens, CD, Humans, Lupus Erythematosus, Systemic, Receptors, Tumor Necrosis Factor, Type II
Vasculitis, Polymorphism, Genetic, Arginine, Receptors, Tumor Necrosis Factor, Autoimmune Diseases, Methionine, Amino Acid Substitution, Asian People, Japan, Antigens, CD, Humans, Lupus Erythematosus, Systemic, Receptors, Tumor Necrosis Factor, Type II
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