A new HaeIII polymorphism at the D21S13 locus
Copyright policy )A new HaeIII polymorphism at the D21S13 locus
DNA markers in the pericentromeric region of human chromosome 21 have shown linkage to a gene for Familial Alzheimer disease (FAD; St. George Hyslop et al. 1987). The limited informativeness of probes for the loci D21S13 and D21S16 have hindered precise mapping of the FAD locus and analysis of non-allelic heterogeneity in FAD (Schellenberg et al. 1988; St. George-Hyslop et al. 1987). We recently described a new EcoRII polymorphism at the D21S13 locus that was very informative in a large FAD pedigree (Pulst et al. 1990a,b). We now report another polymorphism for the D21S13 locus that further increases the informativeness of this locus.
- University of California, Los Angeles United States
- Cedars-Sinai Medical Center United States
Genetic Markers, Blotting, Southern, Polymorphism, Genetic, Chromosomes, Human, Pair 21, Humans, Deoxyribonucleases, Type II Site-Specific, Polymorphism, Restriction Fragment Length
Genetic Markers, Blotting, Southern, Polymorphism, Genetic, Chromosomes, Human, Pair 21, Humans, Deoxyribonucleases, Type II Site-Specific, Polymorphism, Restriction Fragment Length
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