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The use of ion mobility mass spectrometry to assist protein design: a case study on zinc finger fold versus coiled coil interactions

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2015 United Kingdom English Publisher:Royal Society of Chemistry (RSC)Journal:The Analyst, volume 140, pages 2,847-2,856 (issn: 0003-2654, eissn: 1364-5528, Copyright policy )
Authors: Berezovskaya, Y; Porrini, M; Nortcliffe, C; Barran, P E;

doi: 10.1039/c4an00427b

pmid: 25734188

handle: 20.500.11820/8fc8b46e-ce19-4b29-b719-41d3e7f808d2

The use of ion mobility mass spectrometry to assist protein design: a case study on zinc finger fold versus coiled coil interactions

Abstract

A combination of affinity mass spectrometry, collisional activation and ion mobility analysis coupled with molecular dynamics measurements, are used to probe a zinc finger-coiled coil switching peptide system.

Country
United Kingdom
Related Organizations
Keywords

gas-phase, Protein Folding, noncovalent complexes, /dk/atira/pure/subjectarea/asjc/2300/2304, Molecular Sequence Data, specificity, dissociation, Molecular Dynamics Simulation, Biochemistry, Mass Spectrometry, cytochrome-c, Analytical Chemistry, Electrochemistry, Environmental Chemistry, Amino Acid Sequence, cross-sections, Spectroscopy, /dk/atira/pure/subjectarea/asjc/1600/1607, /dk/atira/pure/subjectarea/asjc/1300/1303, in-vacuo, Proteins, Zinc Fingers, stability, constants, Drug Design, conformations, /dk/atira/pure/subjectarea/asjc/1600/1602, Peptides, /dk/atira/pure/subjectarea/asjc/1600/1603

  • BIP!
    Impact byBIP!
    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 13
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
13
Average
Average
Top 10%
Green
bronze
Related to Research communities
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