CASK and its target gene Reelin were co-upregulated in human esophageal carcinoma
Copyright policy )CASK and its target gene Reelin were co-upregulated in human esophageal carcinoma
Calcium/calmodulin-dependent serine protein kinase (CASK) showed overexpression in human esophageal carcinoma by suppression subtractive hybridization. The upregulation of CASK gene and its target gene Reelin in human esophageal carcinoma tissues versus corresponding normal tissues was revealed by reverse transcription polymerase chain reaction (RT-PCR), immunohistochemistry or Western blot. Moreover, RT-PCR results indicated that the expression patterns of CASK and Reelin in human gastric carcinoma and colon carcinoma were different with those in esophageal carcinoma. Therefore, it suggested that CASK and Reelin were associated with tumorigenesis of esophagus and they were co-upregulated in human esophageal carcinoma.
- PEKING UNION MEDICAL COLLEGE China (People's Republic of)
- Chinese Academy of Medical Sciences & Peking Union Medical College China (People's Republic of)
Extracellular Matrix Proteins, Esophageal Neoplasms, Reverse Transcriptase Polymerase Chain Reaction, Cell Adhesion Molecules, Neuronal, Blotting, Western, Serine Endopeptidases, Nerve Tissue Proteins, Up-Regulation, Immunoenzyme Techniques, Reelin Protein, Stomach Neoplasms, Calcium-Calmodulin-Dependent Protein Kinases, Colonic Neoplasms, Carcinoma, Squamous Cell, Humans, RNA, Messenger, Nucleoside-Phosphate Kinase, Guanylate Kinases
Extracellular Matrix Proteins, Esophageal Neoplasms, Reverse Transcriptase Polymerase Chain Reaction, Cell Adhesion Molecules, Neuronal, Blotting, Western, Serine Endopeptidases, Nerve Tissue Proteins, Up-Regulation, Immunoenzyme Techniques, Reelin Protein, Stomach Neoplasms, Calcium-Calmodulin-Dependent Protein Kinases, Colonic Neoplasms, Carcinoma, Squamous Cell, Humans, RNA, Messenger, Nucleoside-Phosphate Kinase, Guanylate Kinases
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