Sphingosine Kinase-Dependent Migration of Immature Dendritic Cells in Response to Neurotoxic Prion Protein Fragment
Copyright policy )Sphingosine Kinase-Dependent Migration of Immature Dendritic Cells in Response to Neurotoxic Prion Protein Fragment
ABSTRACTThe concept that circulating dendritic cells mediate neuroinvasion in transmissible spongiform encephalopathies received strong support from recent observations that prion protein is expressed in myeloid dendritic cells. We observed that prion protein fragment 106-126 is a chemoattractant for monocyte-derived immature but not mature dendritic cells. Signaling events in chemotaxis involved enzymes downstream of Gqprotein and were inhibited by blockade of sphingosine kinase, suggesting transactivation of sphingosine-1-phosphate-dependent cell motility by prion protein.
- University of Innsbruck Austria
Mice, Phosphotransferases (Alcohol Group Acceptor), Prions, Chemotaxis, Animals, Humans, Dendritic Cells, Peptides, Cells, Cultured, Culture Media, Signal Transduction
Mice, Phosphotransferases (Alcohol Group Acceptor), Prions, Chemotaxis, Animals, Humans, Dendritic Cells, Peptides, Cells, Cultured, Culture Media, Signal Transduction
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