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Synthesis of Pyranicin and Its Inhibitory Action with Bovine Heart Mitochondrial Complex I

descriptionPublicationkeyboard_double_arrow_right Article 06 Feb 2008 English Publisher:American Chemical Society (ACS)Journal:Organic Letters, volume 10, pages 717-720 (issn: 1523-7060, eissn: 1523-7052, Copyright policy )
Authors: Yasunao, Hattori; Shin-ichi, Furuhata; Motonori, Okajima; Hiroyuki, Konno; Masato, Abe; Hideto, Miyoshi; Tetsuhisa, Goto; +1 Authors

doi: 10.1021/ol702902w

pmid: 18251547

Synthesis of Pyranicin and Its Inhibitory Action with Bovine Heart Mitochondrial Complex I

Abstract

Total synthesis of pyranicin was achieved using Cl2Pd(CH3CN)2-catalyzed diastereoselective cyclization of the allylic ester as the key step. The inhibitory activity of this compound for mitochondrial NADH-ubiquinone oxidoreductase (complex I) was slightly poorer than that of ordinary mono-THF acetogenins such as cis-solamin.

Related Organizations
Keywords

Lactones, Electron Transport Complex I, Acetogenins, Molecular Structure, Animals, Annonaceae, Cattle, Fatty Alcohols, Furans, Mitochondria, Heart

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Powered by OpenAIRE graph
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
24
Average
Top 10%
Top 10%
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