Rezeptordichten acetylcholinerger und glutamerger Rezeptoren im 6-OHDA-Hemiparkinson-Modell der Ratte nach intrastriataler Botulinum-Neurotoxin-A-Injektion
Scheel, Melanie;
Rezeptordichten acetylcholinerger und glutamerger Rezeptoren im 6-OHDA-Hemiparkinson-Modell der Ratte nach intrastriataler Botulinum-Neurotoxin-A-Injektion
Für die heutige Therapie des Parkinson mit Levodopa besteht die Problematik schwerer Nebenwirkungen und die Entstehung von Dyskinesen. Ein von uns experimentell entwickelter Therapieansatz mit Botulinum-Neurotoxin-A stellt die Frage, ob dieses Neurotoxin den pathologischen Hypercholinismus beim Morbus Parkinson entgegenwirken kann und so eine neue Therapieform darstellt. Hier sollen die Veränderungen der Rezeptordichten mit Rezeptorautoradiographie für Acetylcholin und Glutamat-Rezeptoren nach intrazerebral applizierten BoNT-A und sham-BoNT im Hemiparkinson-Modell der Ratte untersucht werden.
Germany
- University of Rostock Germany
610 Medical sciences Medicine, info:eu-repo/classification/ddc/610
610 Medical sciences Medicine, info:eu-repo/classification/ddc/610
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