The effects of intermetallic compounds of Ti3Al (α2) and silicide separately on fracture characteristics of Ti-6Al-2Sn-4Zr-2Mo-0.1Si (Ti-62222S) alloy were investigated in this study. The alloys with only Ti3Al and only silicide precipitated were established by aging treatments at temperatures of 913 K followed by air cooling and 1088 K followed by water quenching, respectively. X-ray diffraction analysis results showed that the volume fraction of either Ti3Al or silicide increases with increasing aging time. Tensile properties, namely, yield stress (0.2 pct proof stress), ultimate tensile strenght, and elongation of as-received alloy are much better than those of the aged alloys. The strength of the alloy with only Ti3Al is better than that of the alloy with only silicide, while elongation of the alloy with only silicide is better than that of the alloy with only Ti3Al. Fracture toughness, JIC, of the alloy with only silicide is better than that of the alloy with only Ti3Al. The intergranular fracture appears in the alloy with only Ti3Al. Coarsening of Widmanstatten α structure and increasing ductility of β phase during aging are considered to be effective for increasing fracture toughness.