The polytopic mitochondrial inner membrane proteins MIM17 and MIM23 operate at the same preprotein import site
Copyright policy )The polytopic mitochondrial inner membrane proteins MIM17 and MIM23 operate at the same preprotein import site
Three proteins of the mitochondrial inner membrane are known that are essential for the viability of yeast and seem to be involved in import of preproteins; the integral membrane proteins MIM17 and MIM23 and the peripheral membrane protein MIM44, MIMI7 and MIM23 are homologous to each other in their hydrophobic domain, expose their termini to the intermembrane space, and span the inner membrane up to four times, each. A preprotein in transit across the mitochondrial membrane is specifically cross‐linked to MIM17, MIM23, MIM44, and matrix hsp70. We conclude that MIM17 and MIM23 are integral parts of a preprotein translocation channel and cooperate with MIM44 and hsp70 at the same protein import site.
- University of Amsterdam Netherlands
- University of Freiburg Germany
Saccharomyces cerevisiae Proteins, MIM23, MIM44, Molecular Sequence Data, Saccharomyces cerevisiae, Mitochondrial Membrane Transport Proteins, Fungal Proteins, Mitochondrial Precursor Protein Import Complex Proteins, Amino Acid Sequence, Mitochondrion, Protein Precursors, DNA, Fungal, Protein translocation, MIM17, Base Sequence, Sequence Homology, Amino Acid, 500, hsp70, Membrane Proteins, Membrane Transport Proteins, Biological Transport, Intracellular Membranes, Mitochondria, Repressor Proteins, Carrier Proteins
Saccharomyces cerevisiae Proteins, MIM23, MIM44, Molecular Sequence Data, Saccharomyces cerevisiae, Mitochondrial Membrane Transport Proteins, Fungal Proteins, Mitochondrial Precursor Protein Import Complex Proteins, Amino Acid Sequence, Mitochondrion, Protein Precursors, DNA, Fungal, Protein translocation, MIM17, Base Sequence, Sequence Homology, Amino Acid, 500, hsp70, Membrane Proteins, Membrane Transport Proteins, Biological Transport, Intracellular Membranes, Mitochondria, Repressor Proteins, Carrier Proteins
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).85 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
Citations provided by BIP!Popularity provided by BIP!